Revisiting the Role of Interleukin-1 Pathway in Osteoarthritis: Interleukin-1α and -1β, and NLRP3 Inflammasome Are Not Involved in the Pathological Features of the Murine Menisectomy Model of Osteoarthritis

Background: Innate immune response components such as toll-like receptors (TLRs) and NLRP3-inflammasome act in concert to increase IL-1α/β secretion by synovial macrophages. Previous results suggest that IL-1α/β could be an important mediator involved in the pathogenesis of osteoarthritis (OA). Obje...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Nasi, Sonia, Ea, Hang-Korng, So, Alexander, Busso, Nathalie
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5468399/
https://ncbi.nlm.nih.gov/pubmed/28659793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00282
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