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Integrative proteomics and phosphoproteomics profiling reveals dynamic signaling networks and bioenergetics pathways underlying T cell activation

The molecular circuits by which antigens activate quiescent T cells remain poorly understood. We combined temporal profiling of the whole proteome and phosphoproteome via multiplexed isobaric labeling proteomics technology, computational pipelines for integrating multi-omics datasets, and functional...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Tan, Haiyan, Yang, Kai, Li, Yuxin, Shaw, Timothy I., Wang, Yanyan, Blanco, Daniel Bastardo, Wang, Xusheng, Cho, Ji-Hoon, Wang, Hong, Rankin, Sherri, Guy, Cliff, Peng, Junmin, Chi, Hongbo
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466820/
https://ncbi.nlm.nih.gov/pubmed/28285833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.02.010
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