Amphiregulin contained in NSCLC-exosomes induces osteoclast differentiation through the activation of EGFR pathway

Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related deaths worldwide. The majority of patients are diagnosed in advanced disease stage. Bone metastasis is the most frequent complication in NSCLC resulting in osteolytic lesions. The perfect balance between bone-resorbing os...

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Publicat a:Sci Rep
Autors principals: Taverna, Simona, Pucci, Marzia, Giallombardo, Marco, Di Bella, Maria Antonietta, Santarpia, Mariacarmela, Reclusa, Pablo, Gil-Bazo, Ignacio, Rolfo, Christian, Alessandro, Riccardo
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466625/
https://ncbi.nlm.nih.gov/pubmed/28600504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03460-y
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