Amphiregulin contained in NSCLC-exosomes induces osteoclast differentiation through the activation of EGFR pathway

Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related deaths worldwide. The majority of patients are diagnosed in advanced disease stage. Bone metastasis is the most frequent complication in NSCLC resulting in osteolytic lesions. The perfect balance between bone-resorbing os...

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Pubblicato in:Sci Rep
Autori principali: Taverna, Simona, Pucci, Marzia, Giallombardo, Marco, Di Bella, Maria Antonietta, Santarpia, Mariacarmela, Reclusa, Pablo, Gil-Bazo, Ignacio, Rolfo, Christian, Alessandro, Riccardo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466625/
https://ncbi.nlm.nih.gov/pubmed/28600504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03460-y
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