Amphiregulin contained in NSCLC-exosomes induces osteoclast differentiation through the activation of EGFR pathway

Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related deaths worldwide. The majority of patients are diagnosed in advanced disease stage. Bone metastasis is the most frequent complication in NSCLC resulting in osteolytic lesions. The perfect balance between bone-resorbing os...

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Publicado en:Sci Rep
Autores principales: Taverna, Simona, Pucci, Marzia, Giallombardo, Marco, Di Bella, Maria Antonietta, Santarpia, Mariacarmela, Reclusa, Pablo, Gil-Bazo, Ignacio, Rolfo, Christian, Alessandro, Riccardo
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466625/
https://ncbi.nlm.nih.gov/pubmed/28600504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03460-y
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