Impaired cross-talk between the thioredoxin and glutathione systems is related to ASK-1 mediated apoptosis in neuronal cells exposed to mercury

Mercury (Hg) compounds target both cysteine (Cys) and selenocysteine (Sec) residues in peptides and proteins. Thus, the components of the two major cellular antioxidant systems – glutathione (GSH) and thioredoxin (Trx) systems – are likely targets for mercurials. Hg exposure results in GSH depletion...

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Publicat a:Redox Biol
Autors principals: Branco, Vasco, Coppo, Lucia, Solá, Susana, Lu, Jun, Rodrigues, Cecília M.P., Holmgren, Arne, Carvalho, Cristina
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2017
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466585/
https://ncbi.nlm.nih.gov/pubmed/28600984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.05.024
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