Impaired cross-talk between the thioredoxin and glutathione systems is related to ASK-1 mediated apoptosis in neuronal cells exposed to mercury

Mercury (Hg) compounds target both cysteine (Cys) and selenocysteine (Sec) residues in peptides and proteins. Thus, the components of the two major cellular antioxidant systems – glutathione (GSH) and thioredoxin (Trx) systems – are likely targets for mercurials. Hg exposure results in GSH depletion...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Redox Biol
Autori principali: Branco, Vasco, Coppo, Lucia, Solá, Susana, Lu, Jun, Rodrigues, Cecília M.P., Holmgren, Arne, Carvalho, Cristina
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2017
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466585/
https://ncbi.nlm.nih.gov/pubmed/28600984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.05.024
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