Impaired cross-talk between the thioredoxin and glutathione systems is related to ASK-1 mediated apoptosis in neuronal cells exposed to mercury

Mercury (Hg) compounds target both cysteine (Cys) and selenocysteine (Sec) residues in peptides and proteins. Thus, the components of the two major cellular antioxidant systems – glutathione (GSH) and thioredoxin (Trx) systems – are likely targets for mercurials. Hg exposure results in GSH depletion...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Branco, Vasco, Coppo, Lucia, Solá, Susana, Lu, Jun, Rodrigues, Cecília M.P., Holmgren, Arne, Carvalho, Cristina
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466585/
https://ncbi.nlm.nih.gov/pubmed/28600984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.05.024
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