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Selective and state‐dependent activation of TRESK (K(2P)18.1) background potassium channel by cloxyquin

BACKGROUND AND PURPOSE: Cloxyquin (5‐cloroquinolin‐8‐ol) has been described as an activator of TRESK (K(2P)18.1, TWIK‐related spinal cord K(+) channel) background potassium channel. We have examined the specificity of the drug by testing several K(2P) channels. We have investigated the mechanism of...

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Bibliographic Details
Published in:Br J Pharmacol
Main Authors: Lengyel, Miklós, Dobolyi, Alice, Czirják, Gábor, Enyedi, Péter
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466531/
https://ncbi.nlm.nih.gov/pubmed/28419410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13821
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