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The LQLP Calcineurin Docking Site Is a Major Determinant of the Calcium-dependent Activation of Human TRESK Background K(+) Channel

Calcium-dependent activation of human TRESK (TWIK-related spinal cord K(+) channel, K2P18.1) depends on direct targeting of calcineurin to the PQIIIS motif. In the present study we demonstrate that TRESK also contains another functionally relevant docking site for the phosphatase, the LQLP amino aci...

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Autors principals: Czirják, Gábor, Enyedi, Péter
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207969/
https://ncbi.nlm.nih.gov/pubmed/25202008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.577684
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