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Cucurbitacin E reduces obesity and related metabolic dysfunction in mice by targeting JAK-STAT5 signaling pathway

Several members of cucurbitaceae family have been reported to regulate growth of cancer by interfering with STAT3 signaling. In the present study, we investigated the unique role and molecular mechanism of cucurbitacins (Cucs) in reducing symptoms of metabolic syndrome in mice. Cucurbitacin E (CuE)...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Murtaza, Munazza, Khan, Gulnaz, Aftab, Meha Fatima, Afridi, Shabbir Khan, Ghaffar, Safina, Ahmed, Ayaz, Hafizur, Rahman M., Waraich, Rizwana Sanaullah
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466318/
https://ncbi.nlm.nih.gov/pubmed/28598969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0178910
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