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Mutant TP53 disrupts age-related accumulation patterns of somatic mutations in multiple cancer types
Most cancers are driven by somatic mutations in proto-oncogenes and tumor suppressor genes. Genetic changes in a tumor may accumulate in the tissue self-renewal phase prior to neoplasm. The risk of sporadic mutations increases with age. In this regard, a positive association between patient age and...
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| Publicado no: | Cancer Genet |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5466170/ https://ncbi.nlm.nih.gov/pubmed/27751354 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cancergen.2016.07.001 |
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