Anti-PD-L1 efficacy can be enhanced by inhibition of myeloid derived suppressor cells with a selective inhibitor of PI3Kδ/γ

Checkpoint inhibitors are relatively inefficacious in head and neck cancers, despite an abundance of genetic alterations and a T cell-inflamed phenotype. One significant barrier to efficacy may be the recruitment of myeloid-derived suppressor cells (MDSC) into the tumor microenvironment. Here we dem...

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Bibliografiska uppgifter
I publikationen:Cancer Res
Huvudupphovsmän: Davis, Ruth J., Moore, Ellen C., Clavijo, Paul E., Friedman, Jay, Cash, Harrison, Chen, Zhong, Silvin, Chris, Van Waes, Carter, Allen, Clint
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466078/
https://ncbi.nlm.nih.gov/pubmed/28364000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2534
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