Enhanced tumor control with combination mTOR and PD-L1 inhibition in syngeneic oral cavity cancers

Significant subsets of patients with oral cancer fail to respond to single-agent programmed death (PD) blockade. Syngeneic models of oral cancer were used to determine if blocking oncogenic signaling improved in vivo responses to PD-L1 monoclonal antibody (mAb). Anti-PD-L1 enhanced durable primary t...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Res
Main Authors: Moore, Ellen C., Cash, Harrison A., Caruso, Andria M., Uppaluri, Ravindra, Hodge, James W., Van Waes, Carter, Allen, Clint T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4930724/
https://ncbi.nlm.nih.gov/pubmed/27076449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-15-0252
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