mTOR and MEK1/2 inhibition differentially modulate tumor growth and the immune microenvironment in syngeneic models of oral cavity cancer

We investigated the effects of mTOR and MEK1/2 inhibition on tumor growth and the tumor microenvironment in immunogenic and poorly immunogenic models of murine oral cancer. In vitro, rapamycin and PD901 inhibited signaling through expected downstream targets, but only PD901 reduced viability and alt...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Oncotarget
Главные авторы: Cash, Harrison, Shah, Sujay, Moore, Ellen, Caruso, Andria, Uppaluri, Ravindra, Van Waes, Carter, Allen, Clint
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2015
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742185/
https://ncbi.nlm.nih.gov/pubmed/26506415
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы