mTOR and MEK1/2 inhibition differentially modulate tumor growth and the immune microenvironment in syngeneic models of oral cavity cancer

We investigated the effects of mTOR and MEK1/2 inhibition on tumor growth and the tumor microenvironment in immunogenic and poorly immunogenic models of murine oral cancer. In vitro, rapamycin and PD901 inhibited signaling through expected downstream targets, but only PD901 reduced viability and alt...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Cash, Harrison, Shah, Sujay, Moore, Ellen, Caruso, Andria, Uppaluri, Ravindra, Van Waes, Carter, Allen, Clint
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742185/
https://ncbi.nlm.nih.gov/pubmed/26506415
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