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Regulation of the sperm calcium channel CatSper by endogenous steroids and plant triterpenoids

The calcium channel of sperm (CatSper) is essential for sperm hyperactivated motility and fertility. The steroid hormone progesterone activates CatSper of human sperm via binding to the serine hydrolase ABHD2. However, steroid specificity of ABHD2 has not been evaluated. Here, we explored whether st...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Mannowetz, Nadja, Miller, Melissa R., Lishko, Polina V.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5465908/
https://ncbi.nlm.nih.gov/pubmed/28507119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700367114
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