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Disruption of the principal, progesterone-activated sperm Ca(2+) channel in a CatSper2-deficient infertile patient

The female steroid hormone progesterone regulates ovulation and supports pregnancy, but also controls human sperm function within the female reproductive tract. Progesterone causes elevation of sperm intracellular Ca(2+) leading to sperm hyperactivation, acrosome reaction, and perhaps chemotaxis tow...

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Autors principals: Smith, James F., Syritsyna, Olga, Fellous, Marc, Serres, Catherine, Mannowetz, Nadja, Kirichok, Yuriy, Lishko, Polina V.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637729/
https://ncbi.nlm.nih.gov/pubmed/23530196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1216588110
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