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Disruption of the principal, progesterone-activated sperm Ca(2+) channel in a CatSper2-deficient infertile patient

The female steroid hormone progesterone regulates ovulation and supports pregnancy, but also controls human sperm function within the female reproductive tract. Progesterone causes elevation of sperm intracellular Ca(2+) leading to sperm hyperactivation, acrosome reaction, and perhaps chemotaxis tow...

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Detalhes bibliográficos
Main Authors: Smith, James F., Syritsyna, Olga, Fellous, Marc, Serres, Catherine, Mannowetz, Nadja, Kirichok, Yuriy, Lishko, Polina V.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637729/
https://ncbi.nlm.nih.gov/pubmed/23530196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1216588110
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