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Disruption of the Shc/Grb2 Complex during Abelson Virus Transformation Affects Proliferation, but Not Apoptosis
The v-Abl protein tyrosine kinase encoded by Abelson murine leukemia virus (Ab-MLV) induces pre-B-cell transformation. Signals emanating from the SH2 domain of the protein are required for transformation, and several proteins bind this region of v-Abl. One such protein is the adaptor molecule Shc, a...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2005
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC546584/ https://ncbi.nlm.nih.gov/pubmed/15681433 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.4.2325-2334.2005 |
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