Potent Anti-R5 Human Immunodeficiency Virus Type 1 Effects of a CCR5 Antagonist, AK602/ONO4128/GW873140, in a Novel Human Peripheral Blood Mononuclear Cell Nonobese Diabetic-SCID, Interleukin-2 Receptor γ-Chain-Knocked-Out AIDS Mouse Model

We established human peripheral blood mononuclear cell (PBMC)-transplanted R5 human immunodeficiency virus type 1 isolate JR-FL (HIV-1(JR-FL))-infected, nonobese diabetic-SCID, interleukin 2 receptor γ-chain-knocked-out (NOG) mice, in which massive and systemic HIV-1 infection occurred. The suscepti...

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Autores principales: Nakata, Hirotomo, Maeda, Kenji, Miyakawa, Toshikazu, Shibayama, Shiro, Matsuo, Masayoshi, Takaoka, Yoshikazu, Ito, Mamoru, Koyanagi, Yoshio, Mitsuya, Hiroaki
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2005
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC546550/
https://ncbi.nlm.nih.gov/pubmed/15681411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.4.2087-2096.2005
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