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Detection of a genetic footprint of the sofosbuvir resistance-associated substitution S282T after HCV treatment failure
BACKGROUND: The major resistance-associated substitution for sofosbuvir (S282T) in HCV NS5B causes severe viral fitness costs and rapidly reverts back to prototype in the absence of selection pressure. Accordingly, resistance against sofosbuvir is rarely detected even in patients after treatment fai...
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| Udgivet i: | Virol J |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BioMed Central
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5465446/ https://ncbi.nlm.nih.gov/pubmed/28595606 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12985-017-0779-4 |
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