Detection of a genetic footprint of the sofosbuvir resistance-associated substitution S282T after HCV treatment failure

BACKGROUND: The major resistance-associated substitution for sofosbuvir (S282T) in HCV NS5B causes severe viral fitness costs and rapidly reverts back to prototype in the absence of selection pressure. Accordingly, resistance against sofosbuvir is rarely detected even in patients after treatment fai...

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Dettagli Bibliografici
Pubblicato in:Virol J
Autori principali: Walker, Andreas, Filke, Sandra, Lübke, Nadine, Obermeier, Martin, Kaiser, Rolf, Häussinger, Dieter, Timm, Jörg, Bock, Hans H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2017
Soggetti:
Case Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5465446/
https://ncbi.nlm.nih.gov/pubmed/28595606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12985-017-0779-4
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