Prevalence and impact of baseline resistance-associated substitutions on the efficacy of ledipasvir/sofosbuvir or simeprevir/sofosbuvir against GT1 HCV infection

Baseline resistance-associated substitutions (RASs) have variable impacts in clinical trials but their prevalence and impact in real-world patients remains unclear. We performed baseline resistance testing using a commercial assay (10% cutoff) for 486 patients treated with LDV/SOF or SMV/SOF, with o...

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Publicat a:Sci Rep
Autors principals: Wang, Gary P., Terrault, Norah, Reeves, Jacqueline D., Liu, Lin, Li, Eric, Zhao, Lisa, Lim, Joseph K., Morelli, Giuseppe, Kuo, Alexander, Levitsky, Josh, Sherman, Kenneth E., Frazier, Lynn M., Ramani, Ananthakrishnan, Peter, Joy, Akuskevich, Lucy, Fried, Michael W., Nelson, David R.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5816647/
https://ncbi.nlm.nih.gov/pubmed/29453451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21303-2
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