Prevalence and impact of baseline resistance-associated substitutions on the efficacy of ledipasvir/sofosbuvir or simeprevir/sofosbuvir against GT1 HCV infection

Baseline resistance-associated substitutions (RASs) have variable impacts in clinical trials but their prevalence and impact in real-world patients remains unclear. We performed baseline resistance testing using a commercial assay (10% cutoff) for 486 patients treated with LDV/SOF or SMV/SOF, with o...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Wang, Gary P., Terrault, Norah, Reeves, Jacqueline D., Liu, Lin, Li, Eric, Zhao, Lisa, Lim, Joseph K., Morelli, Giuseppe, Kuo, Alexander, Levitsky, Josh, Sherman, Kenneth E., Frazier, Lynn M., Ramani, Ananthakrishnan, Peter, Joy, Akuskevich, Lucy, Fried, Michael W., Nelson, David R.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5816647/
https://ncbi.nlm.nih.gov/pubmed/29453451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21303-2
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires