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Ndfip1 restricts mTORC1 signalling and glycolysis in regulatory T cells to prevent autoinflammatory disease
Foxp3(+) T regulatory (T(reg)) cells suppress immune cell activation and establish normal immune homeostasis. How T(reg) cells maintain their identity is not completely understood. Here we show that Ndfip1, a coactivator of Nedd4-family E3 ubiquitin ligases, is required for T(reg) cell stability and...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5465375/ https://ncbi.nlm.nih.gov/pubmed/28580955 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15677 |
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