Ndfip1 restricts mTORC1 signalling and glycolysis in regulatory T cells to prevent autoinflammatory disease

Foxp3(+) T regulatory (T(reg)) cells suppress immune cell activation and establish normal immune homeostasis. How T(reg) cells maintain their identity is not completely understood. Here we show that Ndfip1, a coactivator of Nedd4-family E3 ubiquitin ligases, is required for T(reg) cell stability and...

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Foilsithe in:Nat Commun
Main Authors: Layman, Awo Akosua Kesewa, Deng, Guoping, O'Leary, Claire E., Tadros, Samuel, Thomas, Rajan M., Dybas, Joseph M., Moser, Emily K., Wells, Andrew D., Doliba, Nicolai M., Oliver, Paula M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2017
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5465375/
https://ncbi.nlm.nih.gov/pubmed/28580955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15677
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