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NADPH accumulation is responsible for apoptosis in breast cancer cells induced by fatty acid synthase inhibition
Fatty acid synthase (FAS), as a key enzyme involved in de novo lipogenesis, is highly expressed in many cancers. FAS inhibition induces cell death in vivo and in vitro, rendering FAS as an attractive target for cancer therapy, but the defined mechanism is still not well understood. Herein, we confir...
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| Publicat a: | Oncotarget |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Impact Journals LLC
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5464810/ https://ncbi.nlm.nih.gov/pubmed/28427229 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15936 |
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