Rapid and strong human CD8(+) T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909

The induction of potent CD8(+) T cell responses by vaccines to fight microbes or tumors remains a major challenge, as many candidates for human vaccines have proved to be poorly immunogenic. Deoxycytidyl-deoxyguanosin oligodeoxynucleotides (CpG ODNs) trigger Toll-like receptor 9, resulting in dendri...

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Main Authors: Speiser, Daniel E., Liénard, Danielle, Rufer, Nathalie, Rubio-Godoy, Verena, Rimoldi, Donata, Lejeune, Ferdy, Krieg, Arthur M., Cerottini, Jean-Charles, Romero, Pedro
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2005
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC546459/
https://ncbi.nlm.nih.gov/pubmed/15696196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200523373
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