Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy

BACKGROUND. Molecular profiling is revolutionizing cancer diagnostics and leading to personalized therapeutic approaches. Herein we describe our clinical experience performing targeted sequencing for 31 pediatric neuro-oncology patients. METHODS. We sequenced 510 cancer-associated genes from tumor a...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Kline, Cassie N., Joseph, Nancy M., Grenert, James P., van Ziffle, Jessica, Talevich, Eric, Onodera, Courtney, Aboian, Mariam, Cha, Soonmee, Raleigh, David R., Braunstein, Steve, Torkildson, Joseph, Samuel, David, Bloomer, Michelle, Campomanes, Alejandra G. de Alba, Banerjee, Anuradha, Butowski, Nicholas, Raffel, Corey, Tihan, Tarik, Bollen, Andrew W., Phillips, Joanna J., Korn, W. Michael, Yeh, Iwei, Bastian, Boris C., Gupta, Nalin, Mueller, Sabine, Perry, Arie, Nicolaides, Theodore, Solomon, David A.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
Fag:
Pediatric Neuro-Oncology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5464451/
https://ncbi.nlm.nih.gov/pubmed/28453743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now254
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