Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy

BACKGROUND. Molecular profiling is revolutionizing cancer diagnostics and leading to personalized therapeutic approaches. Herein we describe our clinical experience performing targeted sequencing for 31 pediatric neuro-oncology patients. METHODS. We sequenced 510 cancer-associated genes from tumor a...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Kline, Cassie N., Joseph, Nancy M., Grenert, James P., van Ziffle, Jessica, Talevich, Eric, Onodera, Courtney, Aboian, Mariam, Cha, Soonmee, Raleigh, David R., Braunstein, Steve, Torkildson, Joseph, Samuel, David, Bloomer, Michelle, Campomanes, Alejandra G. de Alba, Banerjee, Anuradha, Butowski, Nicholas, Raffel, Corey, Tihan, Tarik, Bollen, Andrew W., Phillips, Joanna J., Korn, W. Michael, Yeh, Iwei, Bastian, Boris C., Gupta, Nalin, Mueller, Sabine, Perry, Arie, Nicolaides, Theodore, Solomon, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Pediatric Neuro-Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5464451/
https://ncbi.nlm.nih.gov/pubmed/28453743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now254
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