Dissecting inherent intratumor heterogeneity in patient-derived glioblastoma culture models

BACKGROUND. Molecular profile of glioblastoma multiforme (GBM) revealed 4 subtypes, 2 of which, proneural and mesenchymal, have been predominantly observed, with the latter displaying a more aggressive phenotype and increased therapeutic resistance. Single-cell RNA sequencing revealed that multiple...

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Udgivet i:Neuro Oncol
Main Authors: Teng, Jian, Carla da Hora, Cintia, Kantar, Rami S., Nakano, Ichiro, Wakimoto, Hiroaki, Batchelor, Tracy T., Chiocca, E. Antonio, Badr, Christian E., Tannous, Bakhos A.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
Fag:
Basic and Translational Investigations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5464448/
https://ncbi.nlm.nih.gov/pubmed/28062830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now253
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