Glioblastoma on a microfluidic chip: Generating pseudopalisades and enhancing aggressiveness through blood vessel obstruction events

BACKGROUND: Glioblastoma (GBM) is one of the most lethal tumor types. Hypercellular regions, named pseudopalisades, are characteristic in these tumors and have been hypothesized to be waves of migrating glioblastoma cells. These “waves” of cells are thought to be induced by oxygen and nutrient deple...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Ayuso, Jose M., Monge, Rosa, Martínez-González, Alicia, Virumbrales-Muñoz, María, Llamazares, Guillermo A., Berganzo, Javier, Hernández-Laín, Aurelio, Santolaria, Jorge, Doblaré, Manuel, Hubert, Christopher, Rich, Jeremy N., Sánchez-Gómez, Pilar, Pérez-García, Víctor M., Ochoa, Ignacio, Fernández, Luis J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
Schlagworte:
Basic and Translational Investigations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5464359/
https://ncbi.nlm.nih.gov/pubmed/28062831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now230
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