Glioblastoma on a microfluidic chip: Generating pseudopalisades and enhancing aggressiveness through blood vessel obstruction events

BACKGROUND: Glioblastoma (GBM) is one of the most lethal tumor types. Hypercellular regions, named pseudopalisades, are characteristic in these tumors and have been hypothesized to be waves of migrating glioblastoma cells. These “waves” of cells are thought to be induced by oxygen and nutrient deple...

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Enregistré dans:
Détails bibliographiques
Publié dans:Neuro Oncol
Auteurs principaux: Ayuso, Jose M., Monge, Rosa, Martínez-González, Alicia, Virumbrales-Muñoz, María, Llamazares, Guillermo A., Berganzo, Javier, Hernández-Laín, Aurelio, Santolaria, Jorge, Doblaré, Manuel, Hubert, Christopher, Rich, Jeremy N., Sánchez-Gómez, Pilar, Pérez-García, Víctor M., Ochoa, Ignacio, Fernández, Luis J.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2017
Sujets:
Basic and Translational Investigations
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5464359/
https://ncbi.nlm.nih.gov/pubmed/28062831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now230
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