Comprehensive molecular characterization of multifocal glioblastoma proves its monoclonal origin and reveals novel insights into clonal evolution and heterogeneity of glioblastomas

BACKGROUND. The evolution of primary glioblastoma (GBM) is poorly understood. Multifocal GBM (ie, multiple synchronous lesions in one patient) could elucidate GBM development. METHODS. We present the first comprehensive study of 12 GBM foci from 6 patients using array-CGH, spectral karyotyping, gene...

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書誌詳細
出版年:Neuro Oncol
主要な著者: Abou-El-Ardat, Khalil, Seifert, Michael, Becker, Kerstin, Eisenreich, Sophie, Lehmann, Matthias, Hackmann, Karl, Rump, Andreas, Meijer, Gerrit, Carvalho, Beatriz, Temme, Achim, Schackert, Gabriele, Schröck, Evelin, Krex, Dietmar, Klink, Barbara
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2017
主題:
Basic and Translational Investigations
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5464316/
https://ncbi.nlm.nih.gov/pubmed/28201779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now231
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