Kv1.3 channel blocker (ImKTx88) maintains blood–brain barrier in experimental autoimmune encephalomyelitis

BACKGROUND: Disruption of blood–brain barrier (BBB) and subsequent infiltration of auto-reactive T lymphocytes are major characteristics of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). Kv1.3 channel blockers are demonstrated potential therapeutic effects on MS patient...

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Vydáno v:Cell Biosci
Hlavní autoři: Huang, Jie, Han, Song, Sun, Qi, Zhao, Yipeng, Liu, Junchen, Yuan, Xiaolu, Mao, Wenqian, Peng, Biwen, Liu, Wanhong, Yin, Jun, He, Xiaohua
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5463463/
https://ncbi.nlm.nih.gov/pubmed/28596825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-017-0158-2
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