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Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in Neuroblastoma
Catechol‐O‐methyltransferase (COMT) is an enzyme that inactivates dopamine and other catecholamines by O‐methylation. Tolcapone, a drug commonly used in the treatment of Parkinson's disease, is a potent inhibitor of COMT and previous studies indicate that Tolcapone increases the bioavailability...
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| Опубликовано в: : | Cancer Med |
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| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
John Wiley and Sons Inc.
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5463066/ https://ncbi.nlm.nih.gov/pubmed/28429453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.1065 |
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