A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer’s disease risk, and increased TREML1 and TREM2 brain gene expression

INTRODUCTION: We hypothesized that common Alzheimer’s disease (AD)-associated variants within the triggering receptor expressed on myeloid (TREM) gene cluster influence disease through gene expression. METHODS: Expression microarrays on temporal cortex and cerebellum from ~400 neuropathologically di...

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Gepubliceerd in:Alzheimers Dement
Hoofdauteurs: Carrasquillo, Minerva M., Allen, Mariet, Burgess, Jeremy D., Wang, Xue, Strickland, Samantha L., Aryal, Shivani, Siuda, Joanna, Kachadoorian, Michaela L., Medway, Christopher, Younkin, Curtis S., Nair, Asha, Wang, Chen, Chanana, Pritha, Serie, Daniel, Nguyen, Thuy, Lincoln, Sarah, Malphrus, Kimberly G., Morgan, Kevin, Golde, Todd E., Price, Nathan D., White, Charles C., De Jager, Philip L, Bennett, David A., Asmann, Yan W., Crook, Julia E., Petersen, Ronald C., Graff-Radford, Neill R., Dickson, Dennis W., Younkin, Steven G., Ertekin-Taner, Nilüfer
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5462884/
https://ncbi.nlm.nih.gov/pubmed/27939925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2016.10.005
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