A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer’s disease risk, and increased TREML1 and TREM2 brain gene expression

INTRODUCTION: We hypothesized that common Alzheimer’s disease (AD)-associated variants within the triggering receptor expressed on myeloid (TREM) gene cluster influence disease through gene expression. METHODS: Expression microarrays on temporal cortex and cerebellum from ~400 neuropathologically di...

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محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Alzheimers Dement
المؤلفون الرئيسيون: Carrasquillo, Minerva M., Allen, Mariet, Burgess, Jeremy D., Wang, Xue, Strickland, Samantha L., Aryal, Shivani, Siuda, Joanna, Kachadoorian, Michaela L., Medway, Christopher, Younkin, Curtis S., Nair, Asha, Wang, Chen, Chanana, Pritha, Serie, Daniel, Nguyen, Thuy, Lincoln, Sarah, Malphrus, Kimberly G., Morgan, Kevin, Golde, Todd E., Price, Nathan D., White, Charles C., De Jager, Philip L, Bennett, David A., Asmann, Yan W., Crook, Julia E., Petersen, Ronald C., Graff-Radford, Neill R., Dickson, Dennis W., Younkin, Steven G., Ertekin-Taner, Nilüfer
التنسيق: Artigo
اللغة:Inglês
منشور في: 2016
الموضوعات:
Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC5462884/
https://ncbi.nlm.nih.gov/pubmed/27939925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2016.10.005
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