In vivo genome editing and organoid transplantation models of colorectal cancer

In vivo interrogation of the function of genes implicated in tumorigenesis is limited by the need to generate and cross germline mutant mice. Here we describe approaches to model colorectal cancer (CRC) and metastasis that rely on in situ gene editing and orthotopic organoid transplantation in mice...

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Detalhes bibliográficos
Publicado no:Nat Biotechnol
Main Authors: Roper, Jatin, Tammela, Tuomas, Cetinbas, Naniye Malli, Akkad, Adam, Roghanian, Ali, Rickelt, Steffen, Almeqdadi, Mohammad, Wu, Katherine, Oberli, Matthias, Sánchez-Rivera, Francisco, Park, Yoona, Liang, Xu, Eng, George, Taylor, Martin S., Azimi, Roxana, Kedrin, Dmitriy, Neupane, Rachit, Beyaz, Semir, Sicinska, Ewa T., Suarez, Yvelisse, Yoo, James, Chen, Lillian, Zukerberg, Lawrence, Katajisto, Pekka, Deshpande, Vikram, Bass, Adam, Tsichlis, Philip N., Lees, Jacqueline, Langer, Robert, Hynes, Richard O., Chen, Jianzhu, Bhutkar, Arjun J., Jacks, Tyler, Yilmaz, Ömer H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5462879/
https://ncbi.nlm.nih.gov/pubmed/28459449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3836
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