In vivo genome editing and organoid transplantation models of colorectal cancer

In vivo interrogation of the function of genes implicated in tumorigenesis is limited by the need to generate and cross germline mutant mice. Here we describe approaches to model colorectal cancer (CRC) and metastasis that rely on in situ gene editing and orthotopic organoid transplantation in mice...

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Bibliografske podrobnosti
izdano v:Nat Biotechnol
Main Authors: Roper, Jatin, Tammela, Tuomas, Cetinbas, Naniye Malli, Akkad, Adam, Roghanian, Ali, Rickelt, Steffen, Almeqdadi, Mohammad, Wu, Katherine, Oberli, Matthias, Sánchez-Rivera, Francisco, Park, Yoona, Liang, Xu, Eng, George, Taylor, Martin S., Azimi, Roxana, Kedrin, Dmitriy, Neupane, Rachit, Beyaz, Semir, Sicinska, Ewa T., Suarez, Yvelisse, Yoo, James, Chen, Lillian, Zukerberg, Lawrence, Katajisto, Pekka, Deshpande, Vikram, Bass, Adam, Tsichlis, Philip N., Lees, Jacqueline, Langer, Robert, Hynes, Richard O., Chen, Jianzhu, Bhutkar, Arjun J., Jacks, Tyler, Yilmaz, Ömer H.
Format: Artigo
Jezik:Inglês
Izdano: 2017
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5462879/
https://ncbi.nlm.nih.gov/pubmed/28459449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3836
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