Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer

Colorectal cancer (CRC) is a leading cause of death, yet facile preclinical models that mimic the natural stages of CRC progression are lacking. Through the orthotopic engraftment of colon organoids we describe a broadly usable immunocompetent CRC model that recapitulates the entire adenoma-adenocar...

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Detalhes bibliográficos
Publicado no:Nat Biotechnol
Main Authors: O’Rourke, Kevin P, Loizou, Evangelia, Livshits, Geulah, Schatoff, Emma M, Baslan, Timour, Manchado, Eusebio, Simon, Janelle, Romesser, Paul, Leach, Benjamin, Han, Teng, Pauli, Chantal, Beltran, Himisha, Rubin, Mark A, Dow, Lukas E, Lowe, Scott W
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5462850/
https://ncbi.nlm.nih.gov/pubmed/28459450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3837
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