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The murine catecholamine methyltransferase mTOMT is essential for mechanotransduction by cochlear hair cells

Hair cells of the cochlea are mechanosensors for the perception of sound. Mutations in the LRTOMT gene, which encodes a protein with homology to the catecholamine methyltransferase COMT that is linked to schizophrenia, cause deafness. Here, we show that Tomt/Comt2, the murine ortholog of LRTOMT, has...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Cunningham, Christopher L, Wu, Zizhen, Jafari, Aria, Zhao, Bo, Schrode, Kat, Harkins-Perry, Sarah, Lauer, Amanda, Müller, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5462538/
https://ncbi.nlm.nih.gov/pubmed/28504928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.24318
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