Inhibition of HIV-1 gene expression by retroviral vector-mediated small-guide RNAs that direct specific RNA cleavage by tRNase ZL

The tRNA 3′-processing endoribonuclease (tRNase Z or 3′ tRNase; EC 3.1.26.11) is an essential enzyme that removes the 3′ trailer from pre-tRNA. The long form (tRNase ZL) can cleave a target RNA in vitro at the site directed by an appropriate small-guide RNA (sgRNA). Here, we investigated whether thi...

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Main Authors: Habu, Yuichiro, Miyano-Kurosaki, Naoko, Kitano, Michiko, Endo, Yumihiko, Yukita, Masakazu, Ohira, Shigeru, Takaku, Hiroaki, Nashimoto, Masayuki, Takaku, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC546152/
https://ncbi.nlm.nih.gov/pubmed/15647506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki164
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