Induced Regulatory T Cells Superimpose Their Suppressive Capacity with Effector T Cells in Lymph Nodes via Antigen-Specific S1p1-Dependent Egress Blockage

Regulatory T cells (Tregs) restrict overexuberant lymphocyte activation. While close proximity between Tregs and their suppression targets is important for optimal inhibition, and literature indicates that draining lymph nodes (LNs) may serve as a prime location for the suppression, signaling detail...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Geng, Shuang, Zhong, Yiwei, Zhou, Xiaoyu, Zhao, Gan, Xie, Xiaoping, Pei, Yechun, Liu, Hu, Zhang, Huiyuan, Shi, Yan, Wang, Bin
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5461288/
https://ncbi.nlm.nih.gov/pubmed/28638384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00663
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