FTY720 blocks egress of T cells in part by abrogation of their adhesion on the lymph node sinus

Egress of lymphocytes from lymphoid tissues is a complex process in which Gαi-mediated signals play a decisive role. We show here that although FTY720, an agonist of the sphingosine 1-phosphate 1 receptor (S1P(1)R), induces S1P(1)R internalization sufficiently in the presence or absence of Gαi2 or G...

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Bibliographic Details
Main Authors: Zhi, Liang, Kim, Pilhan, Thompson, Brian D., Pitsillides, Costas, Bankovich, Alexander J., Yun, Seok-Hyun, Lin, Charles P., Cyster, Jason G., Wu, Mei X.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3167479/
https://ncbi.nlm.nih.gov/pubmed/21788441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1100670
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