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FTY720 blocks egress of T cells in part by abrogation of their adhesion on the lymph node sinus
Egress of lymphocytes from lymphoid tissues is a complex process in which Gαi-mediated signals play a decisive role. We show here that although FTY720, an agonist of the sphingosine 1-phosphate 1 receptor (S1P(1)R), induces S1P(1)R internalization sufficiently in the presence or absence of Gαi2 or G...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3167479/ https://ncbi.nlm.nih.gov/pubmed/21788441 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1100670 |
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