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Electrostatic engineering of the interface between heavy and light chains promotes antibody Fab fragment production

Monoclonal antibodies and antibody fragments are used for diverse diagnostic and therapeutic applications. We have investigated the secretory production of Fab fragments from insect cells cotransfected with plasmid vectors carrying heavy- and light-chain genes. In the present study, to promote the f...

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Bibliografski detalji
Izdano u:Cytotechnology
Glavni autori: Ohmuro-Matsuyama, Yuki, Mori, Keita, Hamada, Hirotsugu, Ueda, Hiroshi, Yamaji, Hideki
Format: Artigo
Jezik:Inglês
Izdano: Springer Netherlands 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5461237/
https://ncbi.nlm.nih.gov/pubmed/26856589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10616-016-9955-4
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