Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity.

PD134308 and PD135158 are potent and selective antagonists at the cholecystokinin type B (CCK-B) receptors with IC50 values of 1.6 nM and 3.5 nM, respectively, in the radioligand binding assay and Ke values of 7.82 and 12.9 nM, respectively, in their blocking action on CCK responses in the rat later...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Hughes, J, Boden, P, Costall, B, Domeney, A, Kelly, E, Horwell, D C, Hunter, J C, Pinnock, R D, Woodruff, G N
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 1990
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54610/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1975695/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.17.6728
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