Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity.

PD134308 and PD135158 are potent and selective antagonists at the cholecystokinin type B (CCK-B) receptors with IC50 values of 1.6 nM and 3.5 nM, respectively, in the radioligand binding assay and Ke values of 7.82 and 12.9 nM, respectively, in their blocking action on CCK responses in the rat later...

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Main Authors: Hughes, J, Boden, P, Costall, B, Domeney, A, Kelly, E, Horwell, D C, Hunter, J C, Pinnock, R D, Woodruff, G N
Formato: Artigo
Idioma:Inglês
Publicado: 1990
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC54610/
https://ncbi.nlm.nih.gov/pubmed/1975695
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