Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome

MicroRNA (miRNA)-mediated RNA interference regulates many immune processes, but how miRNA circuits orchestrate aberrant intestinal inflammation during inflammatory bowel disease (IBD) is poorly defined. Here, we report that miR-223 limits intestinal inflammation by constraining the nlrp3 inflammasom...

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Bibliografski detalji
Izdano u:J Exp Med
Glavni autori: Neudecker, Viola, Haneklaus, Moritz, Jensen, Owen, Khailova, Ludmila, Masterson, Joanne C., Tye, Hazel, Biette, Kathryn, Jedlicka, Paul, Brodsky, Kelley S., Gerich, Mark E., Mack, Matthias, Robertson, Avril A.B., Cooper, Matthew A., Furuta, Glenn T., Dinarello, Charles A., O’Neill, Luke A., Eltzschig, Holger K., Masters, Seth L., McNamee, Eóin N.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2017
Teme:
Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460990/
https://ncbi.nlm.nih.gov/pubmed/28487310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160462
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