11β-HSD1 Modulates the Set Point of Brown Adipose Tissue Response to Glucocorticoids in Male Mice

Glucocorticoids (GCs) are potent regulators of energy metabolism. Chronic GC exposure suppresses brown adipose tissue (BAT) thermogenic capacity in mice, with evidence for a similar effect in humans. Intracellular GC levels are regulated by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activity...

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Udgivet i:Endocrinology
Main Authors: Doig, Craig L., Fletcher, Rachel S., Morgan, Stuart A., McCabe, Emma L., Larner, Dean P., Tomlinson, Jeremy W., Stewart, Paul M., Philp, Andrew, Lavery, Gareth G.
Format: Artigo
Sprog:Inglês
Udgivet: Endocrine Society 2017
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460930/
https://ncbi.nlm.nih.gov/pubmed/28368470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2016-1722
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