The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas

Over 90% of chondroblastomas contain a heterozygous mutation replacing lysine 36 with methionine (K36M) in the histone H3 variant H3.3. Here, we show that H3K36 methylation is reduced globally in chondroblastomas and in chondrocytes harboring the same genetic mutation due to inhibition of at least t...

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Udgivet i:Science
Main Authors: Fang, Dong, Gan, Haiyun, Lee, Jeong-Heon, Han, Jing, Wang, Zhiquan, Riester, Scott M., Jin, Long, Chen, Jianji, Zhou, Hui, Wang, Jinglong, Zhang, Honglian, Yang, Na, Bradley, Elizabeth W., Ho, Thai H., Rubin, Brian P., Bridge, Julia A., Thibodeau, Stephen N, Ordog, Tamas, Chen, Yue, van Wijnen, Andre J., Oliveira, Andre M., Xu, Rui-Ming, Westendorf, Jennifer J., Zhang, Zhiguo
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460624/
https://ncbi.nlm.nih.gov/pubmed/27229140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aae0065
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