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PCDH18 is frequently inactivated by promoter methylation in colorectal cancer

Protocadherin18 (PCDH18) was found to be preferentially methylated and inactivated in colorectal cancer (CRC) using bioinformatics tools. However, its biologic role in tumorgenesis remains unclear. Herein, we aimed to elucidate its epigenetic regulation and biological functions in CRC. The methylati...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Zhou, Dan, Tang, Weiwei, Su, Guoqiang, Cai, Mingquan, An, Han-Xiang, Zhang, Yun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460281/
https://ncbi.nlm.nih.gov/pubmed/28588296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03133-w
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