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Reduced Viability of Mice with Lung Epithelial-Specific Knockout of Glucocorticoid Receptor

Glucocorticoid (GC)-responsive epithelial–mesenchymal interactions regulate lung development. The GC receptor (GR) mediates GC signaling. Mice lacking GR in all tissues die at birth of respiratory failure. To determine the specific need for epithelial GR in lung development, we bred triple transgeni...

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Detalhes bibliográficos
Publicado no:Am J Respir Cell Mol Biol
Main Authors: Manwani, Neetu, Gagnon, Stéphane, Post, Martin, Joza, Stephen, Muglia, Louis, Cornejo, Salomon, Kaplan, Feige, Sweezey, Neil B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5459527/
https://ncbi.nlm.nih.gov/pubmed/20042713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2009-0263OC
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